In genome wide association studies (GWAS), families based studies tend to have less power to detect genetic associations than population based studies, such as case-control studies.This can be an issue when testing if genes in a family based GWAS have a direct effect on the phenotype of interest or if the genes act indirectly through a secondary ha
Summary: Background: Early trials of long-term lenalidomide use reported an increased incidence of second primary malignancy (SPM), including acute myeloid leukaemia and myelodysplastic syndrome.Later, meta-analysis suggested the link to be secondary to lenalidomide in combination with melphalan.Methods: Myeloma XI is a large, phase III randomised
The Internet offers increased availability and accessibility of medicinal pharmaceuticals including those containing opioids, sedatives and gamma-aminobutyric acid (GABA) drugs through both legal and illegal routes.Sourcing concerns have been further heightened due to the current severe acute respiratory syndrome coronavirus 2 (COVID-19) pandemic w
Abstract Background This is the first report of Besnoitia bennetti in donkeys in Ireland.B.bennetti, an apicomplexan protozoan parasite specific to equids, is an emerging pathogen in Europe.This parasite forms chronic intracytoplasmic cysts in cells of the mesenchymal lineage, mainly fibroblasts, in the skin, sclera and mucosa.Clinical signs in aff
Appropriate management of agricultural crop residues could result in increases on soil organic carbon (SOC) and help to mitigate gas effect.To distinguish the contributions of SOC and sugarcane (Saccharum spp.) residues to the short-term CO2-C loss, we studied the influence of several tillage systems: heavy offset disk harrow (HO), chisel plow (CP)